Now for a nice little journey down memory lane! Cyrus and friends walk through Main Street, past the Overflowing Commune, around Ghost Rome and into a new area that they haven't been through. When Osiris sent that letter from the East Villa, it must be really, really East!
Side note: A general rule of thumb when drawing comics is to have the action in a given panel flow from left to right. Which really messes with me when I'm drawing the characters walking West, but the panels have them walking to the right - i.e. the East. Am I the only one who gets bugged by that? XD